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MSGPP PAPERS "Toxoplasma gondii Cathepsin L is the primary target of the invasion inhibitory compound LHVS." Eric T. Larson, Fabiola Parussini, My-Hang Huynh, Jonathan D. Giebel, Angela M. Kelley, Li Zhang, Matthew Bogyo, Ethan A. Merritt, Vern B. Carruthers J. Biol. Chem. (2009) e-pub M109.003780 [You can download the paper here.] "Structural genomics of pathogenic protozoa: an overview." Erkang Fan, David Baker, Stanley Fields, Michael H Gelb, Frederick S Buckner, Wesley C Van Voorhis, Eric Phizicky, Mark Dumont, Christopher Mehlin, Elizabeth Grayhack, Mark Sullivan, Christophe Verlinde, George Detitta, Deirdre R Meldrum, Ethan A Merritt, Thomas Earnest, Michael Soltis, Frank Zucker, Peter J Myler, Lori Schoenfeld, David Kim, Liz Worthey, Doug Lacount, Marissa Vignali, Jizhen Li, Somnath Mondal, Archna Massey, Brian Carroll, Stacey Gulde, Joseph Luft, Larry Desoto, Mark Holl, Jonathan Caruthers, Jürgen Bosch, Mark Robien, Tracy Arakaki, Margaret Holmes, Isolde Le Trong, Wim G J Hol Methods Mol Biol. (2008) 426, 497-513 doi 10.1007/978-1-60327-058-8_33 "Glycogen Synthase Kinase 3 is a Potential Drug Target for African Trypanosomiasis Therapy" Oko K.K., Gillespie, J.R., Riechers, A.J., Napuli, A.J., Verlinde, C.L., Buckner, F.S., Gelb, M.J., Domostoj, M.M., Wells, S.J., Scheer A., Wells, T.N., Van Voorhis, W.C. Antimicrob Agents Chemother (2008), doi:10.1128/AAC.00364-08 [You can download the paper as accepted here.] "Structures of substrate-and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity." Larson, E.T., Deng, W., Krumm, B.E., Napuli, A., Mueller, N., Van Voorhis, W.C., Buckner, F.S., Fan, E., Lauricella, A., DeTitta, G., Luft, J., Zucker, F., Hol, W.G.J., Verlinde, C.L.M.J. & Merritt, E.A Journal of Molecular Biology (2008) 381, 975-988, doi:10.1016/j.jmb.2008.06.048 [You can download the paper here.] "Characterization of Trypanosoma brucei dihydroorotate dehydrogenase
as a possible drug target; structural, kinetic and RNAi studies."
Arakaki, T., Buckner, F. S., Gillespie, J. R., Malmquist, N. A.,
Phillips, M.
A., Kalyuzhniy, O., DeTitta, G., Luft, J. R., Verlinde, C. L., Van
Voorhis, W. C., Hol, W. G. & Merritt, E. A. Mol.
Micro. (2008) [2008 Feb 26; Epub ahead of print]doi:10.1111/j.1365-2958.2008.06131.x "The structure of Plasmodium vivax phosphatidylethanolamine-binding
protein suggests a functional motif containing a left-handed helix",
T. Arakaki, H. Neely, E. Boni, N. Mueller, F. S. Buckner, W. C.
Van Voorhis, A. Lauricella, G. DeTitta, J. Luft, W. G. J. Hol and
E. A. Merritt. Acta
Cryst. (2007) F63, 178-182, doi:10.1107/S1744309107007580
"The Closed MTIP-MyosinA-tail Complex from the Malaria Parasite
Invasion Machinery" J. Bosch, S.Turley, C. Roach, T.M. Daly, L.W.
Bergman and W.G. Hol.
J. Mol. Biol., (2007) 372, 77-88 [Epub 2007 Jun
9] 10.1016/j.jmb.2007/06/016 "Structure of the MTIP-MyoA complex, a key component of the malaria
parasite invasion motor" Jürgen Bosch, Stewart Turley, Thomas M.
Daly, Stephen M. Bogh, Michelle L. Villasmil, Claudia Roach, Na
Zhou, Joanne M. Morrisey, Akhil B. Vaidya, Lawrence W. Bergman and
Wim G. J. Hol.
Proceedings of the National Academy of Sciences, [Epub
2006 Mar 17] 10.1073/pnas.0510907103; print 2006 Mar 28;103(13):4852-4857 "Using Fragment Cocktail Crystallography To Assist Inhibitor Design
of Trypanosoma Brucei Nucleoside 2-Deoxyribosyltransferase", Jürgen
Bosch, Mark A. Robien, Christopher Mehlin, Erica Boni, Aaron Riechers,,
Frederick S. Buckner, Wesley C. Van Voorhis, Peter J. Myler, Elizabeth
A. Worthey, George DeTitta, Joseph R. Luft, Angela Lauricella, Stacey
Gulde, Lori A. Anderson, Oleksandr Kalyuzhniy, Helen M. Neely, Jenni
Ross, Thomas N. Earnest, Michael Soltis, Lori Schoenfeld, Frank
Zucker, Ethan A. Merritt, Erkang Fan, Christophe L. M. J. Verlinde,
and Wim G. J. Hol. J.
Med. Chem (2006) 49, 5939-5946, doi:10.1021/jm060429m "Heterologous expression of proteins from Plasmodium falciparum:
Results from 1000 genes", Christopher Mehlin, Erica Boni, Frederick
S Buckner, Linnea Engel, Tiffany Feist, Michael H Gelb, Lutfiyah
Haji, David Kim, Colleen Liu, Natascha Mueller, Peter J Myler, J
T Reddy, Joshua N Sampson, E Subramanian, Wesley C Van Voorhis,
Elizabeth Worthey, Frank Zucker, Wim G J Hol.
Mol Biochem Parasitol [Epub 2006 Apr 18] doi:10.1016/j.molbiopara.2006.03.011;
print 2006 Aug 1;148(2):144-160 "Structure of ribose 5-phosphate isomerase from Plasmodium
falciparum", Margaret A. Holmes, Frederick S. Buckner, Wesley
C. Van Voorhis, Christophe L. M. J. Verlinde, Christopher Mehlin,
Erica Boni, George DeTitta, Joseph Luft, Angela Lauricella, Lori
Anderson, Oleksandr Kalyuzhniy, Frank Zucker, Lori W. Schoenfeld,
Thomas N. Earnest, Wim G. J. Hol and Ethan A. Merritt. Acta
Cryst. (2006 May) F62, 427-431 (Copyright ©
International Union of Crystallography)
"Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major",
Tracy Arakaki, Isolde Le Trong, Eric Phizicky, Erin Quartley, George DeTitta, Joseph Luft, Angela Lauricella, Lori Anderson, Oleksandr Kalyuzhniy, Elizabeth Worthey, Peter J. Myler, David Kim, David Baker, Wim G.J. Hol and Ethan A. Merritt.
Acta Cryst. (2006 March) F62, 175-179.
(Copyright © International Union of Crystallography)
"Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum",
Margaret A. Holmes, Frederick S. Buckner, Wesley C.E. Van Voorhis, Christopher Mehlin, Erica Boni, Thomas N. Earnest, George DeTitta, Joseph Luft, Angela Lauricella, Lori Anderson, Oleksandr Kalyuzhniy, Frank Zucker, Lori W. Schoenfeld, Wim G.J. Hol and Ethan A. Merritt.
Acta Cryst. (2006 March) F62, 180-185.
(Copyright © International Union of Crystallography) "Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum", J. Caruthers, J. Bosch, F. Buckner, W. Van Voorhis, P. Myler, E. Worthey, C. Mehlin, E. Boni, G. DeTitta, J. Luft, A. Lauricella, O. Kalyuzhniy, L. Anderson, F. Zucker, M. Soltis, Wim G. J. Hol. PROTEINS: Structure, Function, and Bioinformatics (2006) Feb 1;62(2):338-342 [You can download the paper here.] "Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25Å Resolution reveals intriguing extra electron density in the active site", Mark A. Robien, Jürgen Bosch, Frederick S. Buckner, Wesley C.E. Van Voorhis, Elizabeth A. Worthey, Peter Myler, Christopher Mehlin, Erica E Boni, Oleksandr Kalyuzhniy, Lori Anderson, Angela Lauricella, Stacy Gulde, Joseph R. Luft, George DeTitta, Jonathan M. Caruthers, Keith O. Hodgson, Michael Soltis, Frank Zucker, Christophe L.M.J. Verlinde, Ethan A. Merritt, Lori W. Schoenfeld and Wim G.J. Hol. PROTEINS: Structure, Function, and Bioinformatics, Epub 2005 Dec 12; print 2006 62: 570-577 "Crystal structures and proposed structural/functional classification
of three protozoan proteins from the isochorismatase superfamily",
Jonathan Caruthers, Frank Zucker, Elizabeth Worthey, Peter J Myler,
Fred Buckner, Wes Van Voorhuis, Chris Mehlin, Erica Boni, Tiffany
Feist, Joseph Luft, Stacey Gulde, Angela Lauricella, Oleksandr Kaluzhniy,
Lori Anderson, Isolde Le Trong, Margaret A Holmes, Thomas Earnest,
Michael Soltis, Keith O Hodgson, Wim G J Hol and Ethan A Merritt.
Protein Science (2005) [Epub Sep 30] print Nov, 14(11):2887-2894 "Structures of Plasmodium falciparum purine nucleoside
phosphorylase complexed with sulfate and its natural substrate inosine",
Claudia Schnick, Mark A. Robien, Andrzej M. Brzozowski, Eleanor
J. Dodson, Garib N. Murshudov, Lori Anderson, Joseph R. Luft, Chris
Mehlin, Wim G. J. Hol, James A. Brannigan and Anthony J. Wilkinson.
Acta Cryst Section D. (2005) Sep;61(Pt 9):1245-1254.
[Epub 2005 Aug 16[ "Automated Prediction of Domain Boundaries in CASP6 Targets Using
Ginzu and RosettaDOM", Kim, D.E., Chivian, D., Malmstrom, L., and
Baker, D. Proteins (2005) [Epub ahead of print Sep 26] 61
Suppl 7: 193-200 "Prediction of CASP-6 structures using automated Robetta protocols",
Chivian, D., Kim, D.E., Malmstrom, L., Rohl, C.A., Schonbrun, J.,
and Baker, D. Proteins (2005) [Epub ahead of print Sep 26]
61 Suppl 7:157-166 "Rapid Isolation of Antibodies for Structural Genomics", Shea,
C., Bloedorn, L. and Sullivan, MA. Journal of Structural and
Functional Genomics (2005) 6(2-3):171-175. "A Protein Interaction Network of the Malaria Parasite Plasmodium
falciparum", Douglas LaCount, Marissa Vignali, Rakesh Chettier,
Amit Phansalkar, Russell Bell, Jay Hesselberth, Lori Schoenfeld,
Irene Ota, Sudhir Sahasrabuhde, Cornelia Kurschner, Stanley Fields
and Robert Hughes. Nature (2005) Nov 3;438(7064):103-107. "Structure-Based Drug Discovery for Plasmodium falciparum",
Christopher Mehlin. Combinatorial Chemistry & High Throughput
Screening (2005) 8, 5-14. "Protein structure prediction and analysis using the Robetta server",
David E. Kim, Dylan Chivian and David Baker. Nucleic Acids Research
(2004) Jul 1;32(Web Server issue):W526-531. DOI: 10.1093/nar/gkh468 "Automated affinity chromatography measurements of compound mixtures
using a lab-on-valve apparatus coupled to electrospray ionization
mass spectrometry", Yuko Ogata, Louis Scampavia, Tyan L. Carter,
Erkang Fan, and Frantinek Turebeka. Analytical Biochemistry
(2004) Aug 1;331(1):161-168. "Cloning grills: High throughput cloning for structural genomics",
Christopher Mehlin, Erica E. Boni, Jamie Andreyka and Richard W.
Terry. Journal of Structural and Functional Genomics (2004)
5(1-2):59-61. "Solid-phase synthesis of 1,5-substituted 2-(N-alkylamino)-imidazolidin-4-ones",
Jizhen Li, Zhenfa Zhang and Erkang Fan. Tetrahedron Letters
(2004) 45, 1267-1269. "A Facile Method for High-throughput Co-expression of Protein
Pairs", Andrei Alexandrov, Marissa Vignali, Douglas J. LaCount,
Erin Quartley, Christina de Vries, Daniela De Rosa, Julie Babulski,
Sarah F. Mitchell, Lori W. Schoenfeld, Stanley Fields, Wim G. Hol,
Mark E. Dumont, Eric M. Phizicky, and Elizabeth J. Grayhack. Molecular
& Cellular Proteomics (2004) Sep;3(9):934-8. [Epub 2004
Jul 7] "mmLib Python toolkit for manipulating annotated structural
models of biological macromolecules", Jay Painter and Ethan A Merritt.
Journal of Applied Crystallography (2004) 37, 174-178 [doi:10.1107/S0021889803025639]
ISSN 0021-8898. "An improved protocol for rapid freezing of protein samples for
long-term storage", Junpeng Deng, Douglas R. Davies, Goragot Wisedchaisri,
Meiting Wu, Wim G. J. Hol and Christopher Mehlin. Biological
Crystallography (2004) Jan;60(Pt 1):203-204. [Epub 2003 Dec
18] ISSN 0907-4449. "A deliberate approach to screening for initial crystallization
conditions of biological macromolecules", Joseph R. Luft, Robert
J. Collins, Nancy A. Fehrman, Angela M. Lauricella, Christina K.
Veatch, and George T. DeTitta. Journal of Structural Biology
(2003) Apr;142(1):170-179. "TFA-Sensitive Arylsulfonylthiourea-Assisted Synthesis of N,N¢-Substituted
Guanidines", Jizhen Li, Guangtao Zhang, Zhongsheng Zhang, and Erkang
Fan. J. Org. Chem. (2003); 68(4); 1611-1614. DOI: 10.1021/jo026807m
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