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MSGPP - Home
Project Description
  Flow Diagrams
Contact Information
  Program Project Members
Target Diseases & Organisms
* Malaria
   Plasmodium falciparum
   Plasmodium vivax
* Chagas' Disease
    [American Trypanosomiasis]
   Trypanosoma cruzi
* Sleeping Sickness
    [African Trypanosomiasis]
   Trypanosoma brucei
* Leishmaniasis
   Leishmania spp.
* Amoebiasis
   Entamoeba histolytica
* Giardiasis
   Giardia lamblia
* Toxoplasmosis
   Toxoplasma gondii
* Cryptosporidiosis
   Cryptosporidium parvum
Genome Databases
Target Progress
Ligand Screening
Papers by MSGPP
Related Links/Resources
MSGPP

TARGET DISEASES & ORGANISMS


Trypanosoma cruzi
Chagas' Disease

Current Publications/
Reference Articles

History of Publications
for this Disease



Trypanosoma brucei
Sleeping Sickness

Current Publications/
Reference Articles

History of Publications
for this Disease



Leishmania spp
Leishmaniasis

Current Publications/
Reference Articles

History of Publications
for this Disease



Plasmodium falciparum
Malaria

Current Publications/
Reference Articles

History of Publications
for this Disease



Plasmodium vivax
Malaria

Current Publications/
Reference Articles

History of Publications
for this Disease



Toxoplasma gondii
Toxoplasmosis

Current Publications/
Reference Articles

History of Publications
for this Disease



Entamoeba histolytica
Amoebiasis

Current Publications/
Reference Articles

History of Publications
for this Disease


Giardia lamblia
Giardiasis

Current Publications/
Reference Articles

History of Publications
for this Disease


Cryptosporidium parvum
Cryptosporidiosis

Current Publications/
Reference Articles

History of Publications
for this Disease


Trypanosomatids, Apicocomplexa and Other Targeted Protozoa
These protozoa afflict approximately 500 million people per year, mostly in the tropics and subtropics. The resulting diseases cause disability, disfigurement, and in some cases death. Vaccines against these single cell organisms seem unlikely due to antigenic variation. Additionally, these protozoa promote drug resistance via multiple pathways. The drugs currently available to destroy these parasites are toxic to humans themselves. Overall, our problem with pathogenic protozoa is understudied; however, these issues are pertinent given the human toll.


For T. cruzi there may actually be twice as many genes if you count the two homologs of each, since they may differ by several percent.

Unusual Features of the Targeted Protozoa

  • Antigenic variation and variability of surface proteins
  • Proteins of protozoa that modify host cells and immune response
  • Many surface proteins are attached by GPI anchors
  • Rhoptry organelles, unique to apicoplasts, in Plasmodia
  • Plastid organelles, related to plant chloroplasts, in Plasmodia
  • Flagellar pocket of trypanosomatids, distinct function in secretion and importation
  • Parasitophorous vacuoles surrounding intracellular forms
  • Glycosomes of trypanosomatids
  • Food vacuoles of Plasmodia
  • Trans-splicing of mRNA and lack of introns in trypanosomatids
  • Extensive RNA editing in mitochondria of trypanosomatids
  • Unique transcriptional control of trypanosomatids
  • Plasmodium falciparum sporozoites travel through hepatocytes