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Project Description
  Flow Diagrams
Contact Information
  Program Project Members
Target Diseases & Organisms
* Malaria
   Plasmodium falciparum
   Plasmodium vivax
* Chagas' Disease
    [American Trypanosomiasis]
   Trypanosoma cruzi
* Sleeping Sickness
    [African Trypanosomiasis]
   Trypanosoma brucei
* Leishmaniasis
   Leishmania spp.
* Amoebiasis
   Entamoeba histolytica
* Giardiasis
   Giardia lamblia
* Toxoplasmosis
   Toxoplasma gondii
* Cryptosporidiosis
   Cryptosporidium parvum
Genome Databases
Target Progress
Ligand Screening
Papers by MSGPP
Related Links/Resources
MSGPP


TOXOPLASMOSIS
Tosoplasma gondii


Credit: Image provided by Ke Hu and John Murray.
DOI: 10.1371/journal.ppat.0020020.g001


Toxoplasmosis (Toxoplasma gondii):This zoonosis is spread to humans by ingestion of undercooked meat or oocysts from cat feces. Exposure to this parasite is common, and can lead to serious fetal abnormalities during pregnancy or fatal encephalitis in immune compromised individuals. Treatment options are limited, and need to be given lifelong in immune compromised persons. The potential for introduction of this pathogen into the food supply has resulted in its listing as a Biodefense agent. There is no vaccine for toxoplasmosis


Organism Toxoplasma gondii
At Risk Fetus, HIV infected
Humans Infected Seroprevalence ~10% in USA, ~ 50%-75% in W. Europe
Disease Outcome  
Vaccine Prospects  
Available Drugs Few, may cause severe side-effects
Drug Resistance

 

 

General Information: Medline, Centers for Disease Control